The city had its beginning about 1836, when Pleasant and Ephraim Gray opened a trading post on the site. Ephraim Gray became first postmaster in 1837, naming it after his hometown, Huntsville, Alabama.

Huntsville became the home of Sam Houston, who served as President of the Republic of Texas, Governor of the State of Texas, Governor of Tennessee, U.S. Senator, and Tennessee congressman. Houston led the Texas Army in the Battle of San Jacinto, the decisive victory of the Texas Revolution. He has been noted for his life among the Cherokees of Tennessee, and – near the end of his life – for his opposition to the American Civil War, a very unpopular position in his day. Huntsville has two of Houston’s homes, his grave, and the Sam Houston Memorial Museum. Houston’s life in Huntsville is also commemorated by his namesake Sam Houston State University, and by a 70 ft statue. The towering statue, “A Tribute to Courage” by artist David Adickes, has been described as the world’s largest statue of an American hero, and is easily viewed by travelers on Interstate 45.

Huntsville was also the home of Samuel Walker Houston (1864–1945), a prominent African-American pioneer in the field of education. He was born into slavery on February 12, 1864 to Joshua Houston, a slave owned by Sam Houston. Samuel W. Houston founded the Galilee Community School in 1907, which later became known as the Houstonian Normal and Industrial Institute, in Walker County, Texas.

In 1995, on the grounds of the old Samuel W. Houston Elementary School, the Huntsville Independent School District, along with the Huntsville Arts Commission and the high school’s Ex-Students Association, commissioned the creation of The Dreamers, a monument to underscore the black community’s contributions to the growth and development of Huntsville and Walker County.